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Pemphix (Greek) - Bubble
3 terms share this root
Bullous pemphigoid

Autoimmune disorder the causes "bubble" "like" blisters

  • Bulla (Latin) - Bubble
  • Pemphix (Greek) - Bubble
  • Eidos (Greek) - Form, Resemblance or Shape, Likeness
  • Blisters are in the space between the epidermis and dermis
  • Linear pattern on immunofluorescence
  • Oral mucosa is not involved
  • Tense bullae that do not rupture easily
  • Negative Nikolsky sign... IgG antibodies attack hemidesmosome, which attach cells to the extracellular matrix, in the basement membrane
  • Paraneoplastic Pemphigus

    "Bubbles" or blistering (pemphigus) occurring "alongside" or because of a neoplasm ("formation of new cells")

    • Para (Greek) - Along, side, beside, near, against, contrary to
    • Neos (Greek) - New, young, youthful
    • Plassein (Greek) - To mold or form
    • Pemphix (Greek) - Bubble
  • Pemphigus which occurs because of a neoplastic tumor the hypothesis is that tumor antigens invoke an autoimmune response which causes blistering characteristic of pemphigus
  • Pemphigus vulgaris

    "Common" "bubbles".

  • Autoimmune skin disorder with IgG against desmoglein, which is a component of desmosomes
  • Positive Nikolsky sign
  • Flaccid intraepidermal bullae
  • Acantholysis
  • Reticular immunofluorescence pattern