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Nekros (Greek) - Dead body, Corpse, Death
13 terms share this root
Acute necrotizing gingivitis

The "sharp" or quickly onset "death" of "gum" tissue.

  • Acuere (Latin) - To Sharpen, sharply onset
  • Nekros (Greek) - Dead body, Corpse, Death
  • Gingiva (Latin) - Gums
  • Aerobic infection, especially Fusobacterium
  • Gum bleeding, pain, and ulceration
  • Opportunistic infection
  • Also known as trench mouth because many soldiers developed it during WWI likely due to the poor conditions and stress
  • Acute tubular necrosis

    A "sharp" or quickly onset "death" of the "small pipes" within the kidney.

    • Acuere (Latin) - To Sharpen, sharply onset
    • Tubulus (Latin) - A small pipe
    • Nekros (Greek) - Dead body, Corpse, Death
  • Injury of the renal tubular epithelial cells, with dead cells clogging the tubules and resulting in obstruction
  • Brown casts
  • Failure to concentrate urine
  • Intrarenal azotemia
  • Causes include ischemia, aminoglycosides, heavy metals, myoglobinuria, ethylene glycol, contrast dye, and urate
  • Coagulative necrosis

    A "condition" in which lack of oxygen causes "death" of cells, resulting in "curdling" of tissue.

    • Coagulare (Latin) - To Cause to Curdle
    • Nekros (Greek) - Dead body, Corpse, Death
    • Osis (Greek) - A condition, disease
  • Ischemia results in necrosis, but the architecture of the dead tissue is maintained for a few days due to the denaturation of structural proteins and lysosomal enzymes, which prevents proteolysis from occurring before regeneration begins.
  • While ischemia in most tissues will cause coagulative necrosis, it is important to note that in the central nervous system, ischemia causes liquefactive necrosis because there is very little structural framework in neural tissue.
  • Contraction band necrosis

    A form of tissue "death" in which muscle fibers of the heart "shorten" forming a "strip" .

    • Contrahere (Latin) - To Draw Together
    • Band (Old Norse) - The strip that ties or constrains
    • Nekros (Greek) - Dead body, Corpse, Death
    • Osis (Greek) - A condition, disease
  • Heart attack, myocardial infarction, reperfusion, thick eosinophilic band, contraction bands
  • Uncontrolled cell death unique to cardiac muscle cells that is thought to arise due to reperfusion (oxidative damage that occurs when the blood supply returns to a tissue after a period of ischemia) from hyper contraction, resulting in sarcolemmal rupture
  • Histologically, it is a finding of a recent heart attack and shows contraction bands, which are thick and intensely eosinophilic staining bands.
  • The contractile machinery of the heart is activated due to calcium in the setting of ischemia or activated due to low ATP causing hyper contraction that leads to reperfusion and eventual contraction band necrosis.
  • Diffuse cortical necrosis

    The "death" of the "outer layer" of the kidney.

    • Diffus (Latin) - Poured Out
    • Cortex (Latin) - Bark of a Tree, Outer layer
    • Nekros (Greek) - Dead body, Corpse, Death
  • Acute renal failure
  • A cause of acute renal failure that is usually caused by diminished renal arterial perfusion secondary to vascular spasm, microvascular injury, or intravascular coagulation. It is recognized as the pathological progression of acute tubular necrosis.
  • Fibrinoid necrosis

    Tissue "death" with accumulation of proteinaceous material "resembling" "fibrin."

    • Fibra (Latin) - A fiber, filament, entrail
    • Eidos (Greek) - Form, Resemblance or Shape, Likeness
    • Nekros (Greek) - Dead body, Corpse, Death
  • Associated with immune vasculitis, malignant hypertension, and preeclampsia
  • Seen in blood vessels
  • Necrosis

    Cell "death" as a result of external injury. Unregulated and does not require ATP, unlike apoptosis.

    • Nekros (Greek) - Dead body, Corpse, Death
  • Coagulative
  • Liquefactive
  • Caseous
  • Fatty
  • Fibrinoid
  • Gangrenous
  • Look for an unplanned cell death, such as following loss of blood supply to an organ. Apoptosis is a structured process, such as that which occurs when the fingers separate in utero
  • Necrotizing fasciitis

    Infection and "death" of "band" of deep tissues from S. pyogenes. Aerobic process that produces CH4 and CO2.

    • Nekros (Greek) - Dead body, Corpse, Death
    • Fascia (Latin) - Band, doorframe
  • Flesh eating bacteria
  • Hospital gangrene
  • Bullae formation
  • Gas production
  • Spreads quickly and requires surgical removal of affected area
  • Severe pain and terrible smell with a history of deep puncture wounds
  • Necrotizing ulcerative mucositis

    "Inflammation" on mucous membranes with "dead cell bodies" manifesting as an "ulcer(s)" with a "slimelike" coating

    • Nekros (Greek) - Dead body, Corpse, Death
    • Ulcus (Latin) - A sore, ulcer
    • Mucus (Latin) - Slime, mold, snot
    • Itis (Greek) - Inflammation, pertaining to disease
  • Can be related to Stomatitis, which is an inflammatory process affecting the mucous membranes of the mouth and lips, with or without oral ulceration.
  • Necrotizing ulcerative periodontitis

    "Inflammation" "around" a "tooth" containing "dead cell bodies"

    • Nekros (Greek) - Dead body, Corpse, Death
    • Peri (Greek) - Around, about, beyond
    • Odous (Greek) - Tooth
    • Itis (Greek) - Inflammation, pertaining to disease
  • A type of inflammatory periodontal (gum) disease caused by bacteria (notably fusobacterium and spirochaete species)
  • Rapid rate of attachment loss (loss of alveolar bone)
  • Will show lack of response to conventional periodontal treatment
  • Clinically similar to NUG but is a destructive form of periodontitis leading to loss of clinical attachment and alveolar bone.
  • Palisading necrosis

    Histological appearance of necrosis surrounding tumor cells.

    • Palus (Latin) - Stake
    • Nekros (Greek) - Dead body, Corpse, Death
    • Osis (Greek) - A condition, disease
  • Commonly seen in glioblastoma on histology
  • Renal papillary necrosis

    "Death" of the "nipple"shaped structures of the kidneys

  • Commonly caused by sickle cell disease (or trait), algesic use, diabetes mellitus, or severe pyelonephritis
  • Tumor necrosis factor

    Produced in inflammatory response and causes "swelling" and cellular "death."

    • Tumere (Latin) - To swell
    • Nekros (Greek) - Dead body, Corpse, Death
    • Facere (Latin) - To do, To make
  • There are various TNF α inhibitors that work as autoimmune therapeutics
  • Must perform a PPD before administering TNF α inhibitors because TNF α is important in the defense against tuberculosis
  • Also known as cachexin, as it is involved in the cachexia that occurs in chronic diseases