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Globus (Latin) - Sphere, globe
14 terms share this root
Autosomaldominant hyperIgE syndrome (Job syndrome)

Immune disease due to a mutation in Th17 cell leading to impaired recruitment of neutrophils to sites of infection, allowing for opportunistic infections.

  • Auto (Greek) - Self, one's own
  • Soma (Greek) - Body
  • Domint (Latin) - Ruling
  • Hyper (Greek) - Over, beyond, excess
  • Immunis (Latin) - Free, exempt
  • Globus (Latin) - Sphere, globe
  • Syn (Greek) - With, together
  • Droma (Greek) - Running, A Course
  • Presentation: FATED: course Facies, noninflamed staphylococcal Abscess, retained primary Teeth, increased IgE, Dermatologic problems (eczema)
  • The disease is med after the biblical character Job, whose body was covered with boils by Satan
  • Carboxyhemoglobin

    "Spherical" protein in red "blood" cells that usually carries oxygen, but is instead bound to a "carbon" and "oxygen" group

  • Carboxy Hb has decreased oxygen binding capacity and decreased oxygen unloading in tissues...Chronic CO poisoning presents with headaches
  • Classic finding of CO poisoning is cherry red skin color
  • CO exposure from carbon monoxide that has decreased oxygen binding capacity and decreased oxygen unloading in tissues
  • Exhaust and gas heaters
  • PaO2 is normal, SaO2 is decreased
  • Carbon monoxide has 200x more affinity than oxygen for hemoglobin
  • Cryoglobulin

    Abnormal "spherical" proteins that precipitate, or "freeze", in the blood at low temperatures.

    • Kryos (Greek) - Frost, Crystal
    • Globus (Latin) - Sphere, globe
  • Immunoglobulins in the blood that are insoluble at lower temperature, they are not the same as cold agglutinins, they are associated with Multiple Myeloma, hepatitis C infection, SLE and Rheumatoid Arthritis
  • Globin

    A "spherical" protein

    • Globus (Latin) - Sphere, globe
  • May bind oxygen and heme
  • Composed primarily of soluble alpha helixes
  • Prominent examples include hemoglobin and myoglobin
  • Globose nucleus

    The deep cerebellar "spherical" shaped "kernel" located between the emboliform nucleus and fastigial nucleus.

    Globus pallidus

    A "pale" structure of the basal ganglia of the brain that helps regulate voluntary movement.

  • Split into the internal and external globus pallidus
  • Works with the striatum and substantia nigra to help regulate voluntary movement
  • The origin of the me is not known as the structure does not in fact resemble, as the me implies, a pale colored globe.
  • Haptoglobin

    A blood protein that "fastens" onto free hemoglobin that has been released from RBCs

    • Hapto (Greek) - Touch, Fasten
    • Globus (Latin) - Sphere, globe
  • Spleen identifies hemoglobinhaptoglobin complex and removes it
  • Haptoglobin exists in most animals, but for some reason chickens and geese do not have any.
  • HyperIgM syndrome

    A condition in which an "excess" of "spherical" proteins which "exempt" the body from disease (IgM) causes a set of symptoms that 'run" "together".

    • Hyper (Greek) - Over, beyond, excess
    • Immunis (Latin) - Free, exempt
    • Globus (Latin) - Sphere, globe
    • Syn (Greek) - With, together
    • Droma (Greek) - Running, A Course
  • Xlinked recessive disorder in which a defective CD40 ligand on T helper cells prevents the ability of B cells to undergo antibody class switching to IgG, IgA, and IgE
  • Severe pyogenic infections early in life
  • Infections with opportunistic pathogens, such as Pneumocystis, Cryptosporidium, CMV
  • Literally "excess IgM."
  • Immunoglobulin

    A "spherical" protein made my the cells that keep the body "exempt from disease" in order to fight off infection.

  • Mature B lymphocytes differentiate in germinal centers of lymph nodes by isotype switching into plasma cells that secrete IgG, IgA, IgM, IgD, IgE
  • Decreased in Bruton agammaglobulinemia, Selective IgA deficiency, common variable immunodeficiency
  • Methemoglobin

    "Ball" of "blood" that has oxidized form of hemoglobin "in the midsts of" reduced affinity for O2 but increased affinity for cyanide.

    • Meta (English) - Beyond, in the midst of
    • Haima (Greek) - Blood
    • Globus (Latin) - Sphere, globe
  • Involved in cyanide poisoning
  • To treat cyanide poisoning, using nitrites to induce methemoglobin, which will bind up cyanide, then give thiosulfate to bind cyanide, which will form thiocyanate (renally excreted), and give Vit E or methylene blue to reduce methemoglobin
  • Paroxysmal nocturnal hemoglobinuria

    The presence of "sphere" shaped proteins containing "blood" in the "urine" that is "sudden onset" at "night"

  • Rare hereditary disorder with complement induced intravascular hemolysis due to CD55 and CD59 receptor deficiencies
  • MarchiafavaMicheli syndrome, me is a misnomer presented with hemoglobinuria in the morning because of increased acidity when sleeping which leads to increased activation of the complement system
  • Selective IgA deficiency

    A primary "failure" of the immune system characterized by the lack of a "single" type of "spherical" protein that helps "exempt" the body from infection (IgA) in the blood and secretions.

  • IgA normally protects against infections of the mucous membranes.
  • People are usually asymptomatic, but have increased frequency of infections, especially respiratory, digestive, and GI systems.
  • Transfusion aphylaxis, celiac disease
  • IgA was first identified by Graber and Williams in 1952
  • The first patients with selective IgA deficiency were described 10 years later.
  • Waldenstrom macroglobulinemia

    A "large" "globe" of white "blood" cells.

    • Makros (Greek) - Large, large to scale
    • Globus (Latin) - Sphere, globe
    • Haima (Greek) - Blood
  • Slow growing tumor of B cells what produce large amounts of IgM. Due to the increase in B cells there is a decrease in production of other cell types in the bone marrow leading to anemia
  • Characterized by high levels IgM in the blood
  • The me of the disease comes literally from the fact that there is excess amounts of IgM in the blood
  • Xlinked (Bruton) agammaglobulinemia

    "Without" "immunoglobulins" in the "blood."

    • X - Chromosome med by Hermann Henking in 1890 from x (signifying the unknown) due to some baffling properties he had observed
    • Gelenk (Greek) - Joint
    • A (Greek) - Not, Without
    • Gamma (Greek) - The me of the third letter of the Greek alphabet; signifies gamma globulin
    • Globus (Latin) - Sphere, globe
    • Haima (Greek) - Blood
  • X linked disease. Bruton's Tyrosine Kinase enzyme problem
  • Because of the lack of immunoglobulin, patients are extremely prone to bacterial infections
  • Common infections are caused by encapsulated bacteria
  • The doctor who described the condition noticed it in children that were unable to develop an immunity to infections