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Facere (Latin) - To do, To make
9 terms share this root
Bone marrow defect

“Bone” “marrow” that has been “done” “away” or “made” “off” or abnormal

  • Ban (Old English) - Bone, tusk
  • Mearg (Old English) - Marrow
  • De (Latin) - Away, Off, Down
  • Facere (Latin) - To do, To make
  • May be detected by dental radiographs
  • Common in extraction sites
  • May be indicative of metastatic disease
  • Decayaccelerating factor

    A protein that "speeds up" the "destruction" of cells attacked by the complement system.

  • DAF
  • Paroxysmal nocturnal hemoglobinuria
  • GPIanchored protein
  • Complement mediated hemolysis
  • A membrane protein that interacts with C4b and C3b and interferes with the activation of the complement system. Since DAF is a GPI anchored protein, decreased levels of GPI (as seen in paroxysmal nocturnal hemoglobinuria) leads to complement mediated hemolysis.
  • Factor V leiden

    Abnormal variant of factor V that cannot be inactivated by protein C, resulting in hypercoagulability

    • Facere (Latin) - To do, To make
  • Affected at increased for risk deep vein thrombosis, pulmonary embolism, and transient ischemic attack
  • Named after the city Leiden in the Netherlands where it was identified in 1994

  • MedyQuestion
    • A 33 year old man with no known medical history, presents to the emergency room with complaint of shortness of breath. The patient reports that it started suddenly about an hour earlier. ECG and chest xray at this time were normal. On physical examination, the patient is tachycardic with a heart rate of 157 and a blood pressure of 98/60. The patient is saturating 78% on room air. On history, the patient denies any long flights or recent surgery. What is the most likely genetic cause of this patient’s condition?

    USMLE Step 1

    Granulocyte macrophage colonystimulating factor

    A cytokine secreted by immune cells to stimulate myeloid precursor differentiation into granulocytes and monocytes

    • Granum (Latin) - Grain, seed
    • Cytos (Greek) - Cell, A Hollow, Receptacle, Vessel
    • Colonia (Latin) - Settlement
    • Makros (Greek) - Large, large to scale
    • Phagein (Greek) - To eat, eater of
    • Stimulat (Latin) - Urged
    • Facere (Latin) - To do, To make
  • Treatment for aplastic anemia
  • Mullerian inhibitory factor

    Sertoli cells secrete MIF, which "forbids" paramesonephric ducts from "doing" it's normal development and subsequently causes male development.

  • Sertoli cells, mesonephric duct
  • Osteoclast activating factor

    It is an interleukin responsible for inflammation that is told what "to do" by macrophages and other immune cells. It also is involved in stimulating "break" down of "bone."

  • Also known as IL1a
  • Promotes inflammation, fever, and sepsis
  • Saponification

    The process of "making" "soap".

  • Occurs in fat necrosis/pancreatitis where fatty acids are released. When they are released, calcium can bind to the fatty acids and form soap, which can be seen grossly and microscopically.
  • Tumor necrosis factor

    Produced in inflammatory response and causes "swelling" and cellular "death."

    • Tumere (Latin) - To swell
    • Nekros (Greek) - Dead body, Corpse, Death
    • Facere (Latin) - To do, To make
  • There are various TNF α inhibitors that work as autoimmune therapeutics
  • Must perform a PPD before administering TNF α inhibitors because TNF α is important in the defense against tuberculosis
  • Also known as cachexin, as it is involved in the cachexia that occurs in chronic diseases
  • Vonwillenbrand Factor

    Med after Dr. VonWillebrand. "Makes" primary clot.

    • Facere (Latin) - To do, To make
  • A protein in the blood involved in forming a primary blood clot by aiding in the binding of platelets and stabilizing clotting factor VIII.