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Ase (English) - Used to form the me of enzymes
24 terms share this root
Adenylate Cyclase

Enzyme that converts ATP to cAMP

  • Adenosine (English) - Blend of Adenine and Ribose
  • Cyclo (Greek) - Wheel, Circular
  • Ase (English) - Used to form the me of enzymes
  • Present in bacteria E. Coli, B. anthracis, B. pertussis, M. tuberculosis, Y. pestis, A. hydrophila
  • Aromatase

    An "enzyme" responsible for a key step in the biosynthesis of estrogen, an important factor in sexual development (helps convert androgens (male hormone) to estrogen (female hormone).

    • Aromatic (French) - Obsolete
    • Ase (English) - Used to form the me of enzymes
  • Excess aromatase activity in boys, it can lead to gynecomastia, and in girls to precocious puberty and gigantomastia. In both sexes, early epiphyseal closure leads to short stature
  • Accumulations of androgens low aromatase leads to accumulation of androgens leading to virilization of a female at birth (males are not affected). Females will have primary amenorrhea. Individuals of both sexes will be tall, as lack of estrogen does not bring the epiphyseal lines to closure.
  • Arylsulfatase

    A type of "enzyme" med for its ability to remove sulfur (med the "bringer of light" because heating it caused it to light up) from an aromatic group.

    • Aromaticus (Greek) - Aroma
    • Sulphur (Latin) - Brimstone, sulfur
    • Ase (English) - Used to form the me of enzymes
  • Arylsulfatase A deficiency: Metachromatic leukodystrophy
  • Presents as central and peripheral demyelination with ataxia and dementia
  • Carboxylase

    An "enzyme" that catalyzes transfer of a functional group containing one "carbon" and two "oxygen"

    • Carbo (English) - Carbon
    • Oxys (Greek) - Sharp
    • Ase (English) - Used to form the me of enzymes
  • It uses biotin as a cofactor
  • Caspase

    Intracellular "enzymes" that break down proteins and function to cause regulated cell death.

    • Ase (English) - Used to form the me of enzymes
  • Rupture of the mitochondrial membrane leads to the releases of caspases into the cell that degrade proteins
  • Collagenase

    An "enzyme" used to break down the "glue" like protein, collagen

    • Kolla (Greek) - Glue
    • Genes (Greek) - Born of, produced by; origin or source
    • Ase (English) - Used to form the me of enzymes
  • Enzyme, peptide bonds, muscle cells, Clostridium, gas gangrene, bacteria, immune response
  • Collagenase assist in destroying extracellular structures in the pathogenesis of bacteria like Clostridium. It is considered a virulence factor and facilitates the spread of gas gangrene. However, collagenase is being considered as a drug for the treatment of Peyronie's disease (growth of fibrous plaques in the soft tissue of the penis).
  • Cyclooxygenase

    An "enzyme" that "produces" a "circular" oxygencontaining chemical compound.

    • Kuklos (Greek) - Circle
    • Oxys (Greek) - Sharp
    • Gene (French) - Something that produces
    • Ase (English) - Used to form the me of enzymes
  • Aka COX enzyme, COX1, COX2, NSAIDS, aspirin, antiinflammatory, prostaglandins
  • An enzyme that catalyzes the breakdown of arachidonic acid from cell membranes to prostaglandins
  • Two isoforms exist COX 1 and COX 2
  • Enzyme inactivated by aspirin and other NSAIDS
  • Dehydrogenase

    An "enzyme" that "removes" a "water" molecule from a protein/molecule.

    • De (Latin) - Away, Off, Down
    • Hydro (Greek) - Water
    • Genos (Greek) - Birth
    • Ase (English) - Used to form the me of enzymes
  • Enzyme
  • Reduction reaction
  • Hydrides
  • D
  • DP
  • Electron acceptor
  • An enzyme that catalyzes reduction reactions resulting in one or more hydrides that are transferred to electron acceptor molecules (such as D and DP).
  • Desmolase

    An "enzyme" that cleaves carboncarbon bonds.

    • Desmos (Greek) - Bond, Chain, Fastening
    • Ase (English) - Used to form the me of enzymes
  • Enzyme, carbon bond, steroid, hormone, reproductive system
  • An enzyme that cleaves and forms carboncarbon bonds. It is important in steroid formation within the body.
  • Endonuclease

    An "enzyme" that cleaves D at phosphodiester bonds "within" the "kernel" or nucleus.

    • Endon (Greek) - Within, Inside, Interl
    • Nucleus (Latin) - Kernel
    • Ase (English) - Used to form the me of enzymes
  • Enzyme
  • D
  • Cleavage
  • Phosphodiester bond
  • Nucleotide
  • Helicase

    An "enzyme" that unwinds "spiral" D at the replication fork.

    • Helix (Greek) - Spiral, coil
    • Ase (English) - Used to form the me of enzymes
  • Helicase was first discovered in E. coli and was known as the D unwinding enzyme.
  • Histaminase

    Enzyme involved in the metabolism, oxidation, and inactivation of histamine in the GI tract

    • Histos (Greek) - Tissue, web, warp
    • Amine (English) - Compound in which one of the hydrogens of ammonia is replaced by a hydrocarbon radical
    • Ase (English) - Used to form the me of enzymes
  • Also produced by eosinophils in order to limit mast cell degranulation reactions
  • Hydrolase

    "Enzyme" that "loosens" chemical bonds with "water."

    • Hydro (Greek) - Water
    • Lyein (Greek) - To loosen
    • Ase (English) - Used to form the me of enzymes
  • Used by neoplastic cells along with collageses to break through and invade the basement membrane
  • Integrase

    An "enzyme" produced by a retrovirus (such as HIV) that enables its genetic material to be "made a part of" the D of the infected cell.

    • Integer (Latin) - To make whole
    • Ase (English) - Used to form the me of enzymes
  • Coded by pol gene in HIV
  • Lactate dehydrogenase

    An "enzyme" that is found extensively in body tissues, such as blood cells and heart muscle. It "removes" "hydride" from lactate which forms pyruvate.

    • Lac (Latin) - Milk
    • De (Latin) - Away, Off, Down
    • Hydro (Greek) - Water
    • Genes (Greek) - Born of, produced by; origin or source
    • Ase (English) - Used to form the me of enzymes
  • A dehydrogenase is an enzyme that transfers a hydride from one molecule to another. Lactate dehydrogenase catalyzes the conversion of pyruvate to lactate and back, as it converts DH to D+ and back
  • Because it is released during tissue damage, it is a marker of common injuries and disease.
  • Lipoxygenase

    An "enzyme" involved in metabolism of "fat" using oxygen to do so.

    • Lipos (Greek) - Fat
    • Oxys (Greek) - Sharp
    • Ase (English) - Used to form the me of enzymes
  • Zileuton is a 5lipoxygese pathway inhibitor that treats asthma
  • Myeloperoxidase

    Neutrophil enzyme from bone "marrow" which produces hypochlorite by "sharply" cutting "through" hydrogen peroxide.

    • Myelos (Greek) - Marrow, the brain
    • Per (Latin) - Through, by means of
    • Oxys (Greek) - Sharp
    • Ase (English) - Used to form the me of enzymes
  • Deficiency associated with Candida infections
  • PANCA is a myeloperoxidase antibody
  • Ornithine transcarbamylase

    "Enzyme" that catalyzes the formation of citrulline. Ornithine is a "straight" chained amino acid with an amino group that goes "over" to the "carbon" of carbamoyl phosphate to create citrulline.

    • Orthos (Greek) - Straight, correct
    • Trans (Latin) - Across, over, beyond
    • Carbo (English) - Carbon
    • Ase (English) - Used to form the me of enzymes
  • Manifests with increased orotic acid with hyperammonemia (contrasted with orotic aciduria)
  • Transcarbamylase deficiency
  • Peroxidase

    An "enzyme" used for cleaving "peroxide" bonds.

    • Per (Latin) - Through, by means of
    • Oxys (Greek) - Sharp
    • Ase (English) - Used to form the me of enzymes
  • A family of enzymes that specifically cleave peroxide bonds.
  • Myeloperoxidase is a bluegreen heme containing pigment that gives sputum its color
  • Converts hydrogen peroxide to bleach
  • Found in neutrophils
  • Catalase is a peroxidase
  • Phosphatase

    An "enzyme" that removes a phosphate group. Phosphate gets it's me as "bringer of light" because it was discovered emitting light when exposed to oxygen.

    • Phosphoros (Greek) - Bringer of light
    • Ase (English) - Used to form the me of enzymes
  • Many important enzymes in the body are phosphatases examples include alkaline phosphatase, prostatic acid phosphatase, and glucose6phosphatase
  • Phosphorylase

    An enzyme the catalyzes the addition of a phosphate group to a molecule from an inorganic source. Phosphate gets it's me as "bringer of light" because it was discovered emitting light when exposed to oxygen.

    • Phosphoros (Greek) - Bringer of light
    • Ase (English) - Used to form the me of enzymes
  • Glycogen phosphorylase is an enzyme involved in the breakdown of glycogen.
  • Protease

    An "enzyme" that breaks down "compounds composed to amino acids"

    • Protein (English) - A compound composed of amino acids
    • Ase (English) - Used to form the me of enzymes
  • PH determines optimal activity in digestive tract
  • Superoxide dismutase

    The "enzyme" that "changes" the free radical superoxide, and "breaks it apart" into oxygen and hydrogen peroxide.

    • Super (Latin) - In excess, above, Beyond
    • Oxys (Greek) - Sharp
    • Dis (Latin) - Not, In a Different Direction, Between
    • Mutare (Latin) - To change
    • Ase (English) - Used to form the me of enzymes
  • SOD1 mutation associated with ALS
  • Reduces superoxide into oxygen and hydrogen peroxide
  • Telomerase

    An "enzyme" which extends the "end" "parts" of chromosomes.

    • Telos (Greek) - The end
    • Meros (Greek) - Part
    • Ase (English) - Used to form the me of enzymes
  • Cri du chat syndrome is a deletion in chromosome 5 resulting in a loss of one copy of telomerase
  • Telomerase activity associated with cancer
  • MEDYMOLOGY