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REPRODUCTIVE PHARMACOLOGY
21 terms share this category
Leuprolide

  • Infertility (pulsatile), prostate cancer(continusous use with flutamide), uterine fibroids(continuous), precocious puberty (continuous)
  • GnRH alog with agonist properties when used in pulsatile fashion
  • Antagonist properties when used in continuous fashion
  • Testosterone

    • Treat hypogodism and promot development of secondary sex characteristics
    • Stimulation of abolism to promote rceovery after burn or injury
    • Agonist at androgen receptors
    • Methyltestosterone

      • Treat hypogodism and promot development of secondary sex characteristics
      • Stimulation of abolism to promote rceovery after burn or injury
      • Agonist at androgen receptors
      • Fisteride

        Antiandrogens

        • BPH, male pattern baldness
        • 5alpha reductase inhibitor
        • Flutamide

          Antiandrogens

          • Prostate carcinoma
          • Nonsteroidal competitive inhibitor of androgens at testosterone receptor
          • Ketocozloe

            Antiandrogens

            • Polycistic ovarian syndrome
            • Inhibit steroid synthesis (inhibit 17,20 desmolase)
            • Spironolactone

              Antiandrogens

              • Polycistic ovarian syndrome
              • Inhibits steroid binding
              • Ethinyl Estradiol

                Estrogens

                • Hypogodism or ovarian failure, menstrual abnormalities, HRT in postmenopausal women
                • Use in men with androgendependent prostate cancer
                • Bind estrogen receptor
                • DES

                  Estrogens

                  • Hypogodism or ovarian failure, menstrual abnormalities, HRT in postmenopausal women
                  • Use in men with androgendependent prostate cancer
                  • Bind estrogen receptor
                  • Mestranol

                    Estrogen

                    • Menstrual abnormalities, OCPs
                    • Bind estrogen receptors
                    • Clomipjene

                      SERMs

                      • Infertility and PCOS
                      • Partial Agonist at estrogen receptor in hypothalamus
                      • Tamoxifen

                        SERMs

                        • ERpositive breast cancer
                        • Bind estrogen receptors
                        • Raloxifen

                          SERMs

                          • Osteoperosis in postmenopausal women
                          • Bind estrogen receptors
                          • Astrozole/Exemestane

                            Aromatase inhibitor

                            • Breast cancer
                            • Reversible inhibition of aromatase enzyme
                            • Progestins

                              Progesterone receptor binder

                              • OCPs
                              • Endometrial cancer
                              • Irregular uterine bleeding
                              • Binds progesterone receptors
                              • Mifepristone (RU486)

                                Progesterone receptor binder

                                • Termite pregncy
                                • Competes with progestins at progesterone receptors
                                • Terbutaline

                                  Beta2 agonist

                                  • Decreases premature uterine contractions, reversible bronchospasm
                                  • Beta2 adrenergic receptor agonist
                                  • Tamsulosin

                                    Alpha1 agonist

                                    • BPH
                                    • Selective Alpha1A,D receptors (found in prostate smooth muscle) antagonists > inhibits smooth muscle contraction
                                    • Sildefil

                                      PDE5 inhibitor

                                      • Efil (English) - Medication Naming Convention
                                    • Erectile dysfunction
                                    • PDE5 inhibitor > increased penile blood flow
                                    • Vardefil

                                      PDE5 inhibitor

                                      • Efil (English) - Medication Naming Convention
                                    • Erectile dysfunction
                                    • PDE5 inhibitor > increased penile blood flow
                                    • Danazol

                                      Androgen

                                      • Endometriosis
                                      • Hereditary angioedema
                                      • Partial agonist at androgen receptors
                                      • MEDYMOLOGY