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IMMUNOLOGICAL PHARMACOLOGY
18 terms share this category
Azathioprine

Immunomodulator

  • Immunosuppressant in autoimmune diseases (SLE, IBD, RA, ITP, MS)
  • Antimetabolite that is a precursor of 6MP > intereferes with nucleic acid synthesis and metabolism
  • MuromobCD3 (OKT3)

    Immunomodulator

    • Immunosuppressant in transplant patients
    • Monoclol antibody > binds to CD3 on T cells > blocks T cell interaction and sigl transduction
    • Aldesleukin (interleukin2)

      Recombint Cytokines

      • Rel cell carcinoma, metastatic melanoma
      • Like IL2, this drug allows for the differentiation of T cells into effector T cells
      • Epoetin alfa (erythropoietin)

        Recombint Cytokines

        • Anemias
        • Like EPO, this drug stimulates erythropoiesis
        • Filgrastim (GCSF)

          Recombint Cytokines

          • Recovery of bone marrow
          • GCSF alog > stimulates proliferation of granulocytes
          • Sargramostim (GCSF)

            Recombint Cytokines

            • Recovery of bone marrow
            • GMCSF alog > stimulates granulocyte and macrophage proliferation
            • IFN alpha

              Recombint Cytokines

              • Hep B+C, Kaposi's sarcoma, leukemias, malignt melanoma
              • Interferes with viruses and activates NK cells
              • Inhibits viral protein synthesis
              • Warns uninfected cells of upcoming attack
              • IFNbeta

                Recombint Cytokines

                • Multiple Sclerosis
                • Interferes with viruses and activates NK cells
                • Inhibits viral protein synthesis
                • Warns uninfected cells of upcoming attack
                • IFNgamma

                  Recombint Cytokines

                  • CGD
                  • Interferes with viruses and activates NK cells
                  • Increases MHCI,II expression and antigen presentation in all cells
                  • Warns uninfected cells of upcoming attack
                  • Oprelvekin (interleukin11)

                    Recombint Cytokines

                    • Thrombocytopenia
                    • IL11 alog > stimulates proliferation of hematopoietic stem cells and megakaryocytes
                    • Thrombopoietin

                      Recombint Cytokines

                      • Thrombocytopenia
                      • A glycoprotein hormone that is used to stimulate megakaryocyte growth and development (platelets)
                      • Digoxin Immune Fab

                        Therapeutic Antibodies

                        • Antidote for digoxin toxicity
                        • Binds digoxin > digoxin can no longer bind to action sites on target cells
                        • Infliximab

                          Therapeutic Antibodies

                          • Ximab (English) - Medication Naming Convention
                        • Crohn's, RA, psoriatic arthritis, ankylosing spondylitis
                        • Monoclol antibody (chimeric) > blocks TNFalpha
                        • Adalimumab

                          Therapeutic Antibodies

                          • Umab (English) - Medication Naming Convention
                        • Crohn's, RA, psoriatic arthritis
                        • Monoclol antibody (human) > blocks TNFalpha
                        • Abciximab

                          Therapeutic Antibodies

                          • Ximab (English) - Medication Naming Convention
                        • Prevent cardiac ischemia
                        • Monoclol antibody > blocks glycoprotein IIb/IIIa > blocks platelet aggregation
                        • Trastuzumab (Herceptin)

                          Therapeutic Antibodies

                          • Zumab (English) - Medication Naming Convention
                        • Block HER2overexpression in breast cancers
                        • Monoclol antibody > blocks HER2/neu receptor > decrease breast cancer progression
                        • Rituximab

                          Therapeutic Antibodies

                          • Ximab (English) - Medication Naming Convention
                        • Bcell nonHodgkin's lymphoma
                        • Monoclol antibody (chimeric) > binds to CD20 and blocks B cells
                        • Omalizumab

                          Therapeutic Antibodies

                          • Zumab (English) - Medication Naming Convention
                        • Severe asthma
                        • Humanized antibody > decreased sensitivity to allergens
                        • MEDYMOLOGY