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HEME ONC PHARMACOLOGY
52 terms share this category
Heparin

Anticoagulant

  • PE, ACS, MI, DVT
  • Activated antithrombin
  • Lepirudin

    Anticoagulant

    • HIT
    • Inhibit thrombin
    • Bivalirudin

      Anticoagulant

      • HIT
      • Inhibit thrombin
      • Hirudin

        Anticoagulant

        • HIT
        • Inhibit thrombin
        • Warfarin (coumadin)

          Anticoagulant

          • Chronic anticoagulation Afib, DVT, after STEMI
          • Inhibits Vit K epoxide reductase reduces synthesis of factors 2, 7, 9 10, Protein C/S
          • Alteplase (tPA)

            Thrombolytic

            • Early MI, early ischemic stroke, thromboembolism
            • Convert plasminogen to plasmin
            • Reteplase (rPA)

              Thrombolytic

              • Early MI, early ischemic stroke, thromboembolism
              • Convert plasminogen to plasmin
              • Tenecteplase (TNKtPA)

                Thrombolytic

                • Early MI, early ischemic stroke, thromboembolism
                • Convert plasminogen to plasmin
                • Aspirin

                  Antiplatelet

                  • Antipyretic, algesic, antiinflammatory, antiplatelet
                  • Irreversibly inhibit COX1 & COX2 via covalent acetylation
                  • Clopidogrel

                    ADP receptor inhibitor

                    • Clop (English) - Medication Naming Convention
                  • ACS, corory stenting
                  • Block ADP receptor, inhibit fibrinogen binding by blocking Gp2b3a receptors
                  • Ticlopidine

                    ADP receptor inhibitor

                    • Clop (English) - Medication Naming Convention
                  • ACS, corory stenting
                  • Block ADP receptor, inhibit fibrinogen binding by blocking Gp2b3a receptors
                  • Prasugrel

                    ADP receptor inhibitor

                    • ACS, corory stenting
                    • Block ADP receptor, inhibit fibrinogen binding by blocking Gp2b3a receptors
                    • Ticagrelor

                      ADP receptor inhibitor

                      • ACS, corory stenting
                      • Block ADP receptor, inhibit fibrinogen binding by blocking Gp2b3a receptors
                      • Cilostazol

                        Antiplatelet

                        • Claudication
                        • Platelet phosphodiesterase 3 inhibitor, increased cAMP and prevents aggregation
                        • Dipyridamole

                          Antiplatelet

                          • Corory vasodilation, prevent thombosis after valve replacement
                          • Platelet phosphodiesterase 3 inhibitor, increased cAMP and prevents aggregation
                          • Abciximab

                            Antiplatelet, Monoclol antibody

                            • Mab (English) - Medication Naming Convention
                          • Percutaneous corory intervention
                          • Unstable angi, NSTEMI
                          • Binds and blocks GP2b/3a fibronogen receptor
                          • Eptifibatide

                            Antiplatelet

                            • Percutaneous corory intervention
                            • Unstable angi, NSTEMI
                            • Binds and blocks GP2b/3a fibronogen receptor
                            • Tirofiban

                              Antiplatelet

                              • Unstable angi, NSTEMI
                              • Inhibits fibrinogen binding to GP2b/3a receptor
                              • Methotrexate (MTX)

                                Antimetabolite, Immunosuppressant

                                • Leukemia, lymphoma, breast cancer, head/neck cancer, RA, psoriasis
                                • Folic acid alog, inhibits dihydrofolate reductase
                                • 5fluorouracil (5FU)

                                  Antimetabolite Nitrogenous base alog

                                  • Colorectal cancer, breast cancer, used topically for basal cell carcinoma
                                  • Pyrimidine alog, inhibits thymidylate synthethase
                                  • Cytarabine (arabinofuranosyl cytidine)

                                    Antimetabolite Cytidine alog

                                    • Leukemia, lymphoma
                                    • Incorperated into D and inhibits D polloimerase
                                    • Azathioprine

                                      Immunosuppresant

                                      • Organ transplantation, RA
                                      • Decreases purine synthesis, incorperated into D and stops further replication
                                      • 6Mercaptopurine

                                        Antimetabolite, Immunosuppressant Purine alog

                                        • ALL,APL, Crohn's, UC
                                        • Decreases purine synthesis
                                        • 6thioguanine (6TG)

                                          Antimetabolite Guanine alog

                                          • Leukemia
                                          • Decreases purine synthesis
                                          • Dactinomycin (actinomycin D)

                                            Antitumor antibiotic

                                            • Wilm's tumor, Ewing's sarcoma, Rhabdomyosarcoma
                                            • Intercalates D
                                            • Doxorubicin (Adriamycin)

                                              Antitumor antibiotic

                                              • Solid and liquid tumors
                                              • Complexes with Topoisomerase II, Free radical damage
                                              • Daunorubicin

                                                Antitumor antibiotic

                                                • Solid and liquid tumors
                                                • Intercalates D
                                                • Bleomycin

                                                  Antitumor antibiotic

                                                  • Testicular tumors, Hodgkin's lymphoma
                                                  • Free radical damage
                                                  • Cyclophosphamide

                                                    Alkylating agent

                                                    • Solid and liquid tumors, brain cancer
                                                    • Crosslinks guanine at N7 following activation in liver
                                                    • Ifosfamide

                                                      Alkylating agent

                                                      • Solid and liquid tumors, brain cancer
                                                      • Crosslinks guanine at N7 following activation in liver
                                                      • Carmustine

                                                        Alkylating agent

                                                        • Mustine (English) - Medication Naming Convention
                                                      • CNS tumors
                                                      • Crosslinks guanine following spontaneous bioactivation
                                                      • Lomustine

                                                        Alkylating agent

                                                        • Mustine (English) - Medication Naming Convention
                                                      • CNS tumors
                                                      • Crosslinks guanine following spontaneous bioactivation
                                                      • Semustine

                                                        Alkylating agent

                                                        • Mustine (English) - Medication Naming Convention
                                                      • CNS tumors
                                                      • Crosslinks guanine following spontaneous bioactivation
                                                      • Streptozocin

                                                        Alkylating agent

                                                        • CNS tumors
                                                        • Crosslinks guanine following spontaneous bioactivation
                                                        • Busulfan

                                                          Alkylating agent

                                                          • CML, bone marrow ablation
                                                          • Crosslinks guanine and adenine
                                                          • Vincristine

                                                            Microtubule inhibitor

                                                            • ALL, lymphoma
                                                            • Binds tubulin dimers, prevents polloimerization

                                                            • MedyQuestion
                                                              • A 52 year old man with hodgkin lymphoma presented to his doctors office with a a week history of increasing numbness in his legs, hands and feet. He has been receiving chemotherapy for 2 weeks. He has diminished sensation to pinprick and light touch. DTRs on physical exam are absent. What chemotherapy drug is most likely causing the side effect profile this individual is experiencing.

                                                              USMLE Step 1

                                                              Vinblastine

                                                              Microtubule inhibitor

                                                              • Testicular, breast, nonsmall cell lung cancers, lymphoma
                                                              • Binds tubulin dimers, prevents polloimerization
                                                              • Paclitaxel (taxols)

                                                                Microtubule inhibitor

                                                                • Ovarian, breast cancer
                                                                • Hyperstabilizes microtubules and prevents remodeling
                                                                • Cisplatin

                                                                  Anticancer

                                                                  • Platin (English) - Medication Naming Convention
                                                                • Crosslinking D
                                                                • Carboplatin

                                                                  Anticancer

                                                                  • Platin (English) - Medication Naming Convention
                                                                • Crosslinking D
                                                                • Etoposide

                                                                  Anticancer

                                                                  • Poside (English) - Medication Naming Convention
                                                                • Topoisomerase II inhibitor
                                                                • Teniposide

                                                                  Anticancer

                                                                  • Poside (English) - Medication Naming Convention
                                                                • Topoisomerase II inhibitor
                                                                • Hydroxyurea

                                                                  Antineoplastic drug

                                                                  • Sickle cell anemia (increases HbF), myeloproliferative disorders
                                                                  • Inhibits ribonucleotide reductase
                                                                  • Prednisone

                                                                    Corticosteroids

                                                                    • One (Greek) - Unique
                                                                    • One (English) - Medication Naming Convention
                                                                    Prednisolone

                                                                    Corticosteroids

                                                                    • One (Greek) - Unique
                                                                    • One (English) - Medication Naming Convention
                                                                    Tamoxifen

                                                                    Antiestrogen

                                                                    • Oxifen (English) - Medication Naming Convention
                                                                  • Antagonist of estrogen receptor
                                                                  • Raloxifen

                                                                    Antiestrogen

                                                                    • Oxifen (English) - Medication Naming Convention
                                                                  • Antagonist of estrogen receptor
                                                                  • Trastuzumab (herceptin)

                                                                    Monoclol antibody

                                                                    • Mab (English) - Medication Naming Convention
                                                                  • Used to treat certain breast cancers
                                                                  • Interferes with HER2/neu receptor
                                                                  • Imatinib (Gleevac)

                                                                    Antileukemia

                                                                    • Nib (English) - Medication Naming Convention
                                                                  • Philadelphia chromosome positive chronic myelogenous leukemia (CML)
                                                                  • Tyrosinekise inhibitor
                                                                  • Rituximab

                                                                    • Mab (English) - Medication Naming Convention
                                                                  • Rheumatoid arthritis, leukemias, lymphomas, multiple myeloma
                                                                  • CD20 receptor antagonist
                                                                  • Vemurafenib

                                                                    V600E mutated BRAF inhibition

                                                                      Bevacizumab

                                                                      • Mab (English) - Medication Naming Convention
                                                                      MEDYMOLOGY